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The APOE ε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice

by abbottmj | Jun 20, 2022 | Uncategorized

The APOE ε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice. Foley KE, Hewes AA, Garceau DT, Kotredes KP, Carter GW, Sasner M, Howell GR.Front Aging Neurosci. 2022 Mar 16;14:838436. doi: 10.3389/fnagi.2022.838436. eCollection...

Improving Mouse Models for the Study of Alzheimer’s Disease

by abbottmj | Jun 20, 2022 | Uncategorized

Improving mouse models for the study of Alzheimer’s disease. Reagan AM, Onos KD, Heuer SE, Sasner M, Howell GR.Curr Top Dev Biol. 2022;148:79-113. doi: 10.1016/bs.ctdb.2021.12.005. Epub 2022 Mar 31.PMID: 35461569

AD/PD Presentations 2022 – Visit us at Booth 18!

by abbottmj | Mar 8, 2022 | Uncategorized

WEDNESDAY, MARCH 16: MODELING LATE-ONSET ALZHEIMER’S DISEASE IN MICE Session Name: Individual Cell Types, Organoids and Animal Models in AD, PD (1) Mechanistic & Translational Aspects Session Time: 08:30-10:30 AM (talk time 8:45 AM) Room Onsite: IS005/#46...

Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study

by abbottmj | Dec 7, 2021 | Uncategorized

Oblak AL, Lin PB, Kotredes KP, Pandey RS, Garceau D, Williams HM, Uyar A, O’Rourke R, O’Rourke S, Ingraham C, Bednarczyk D, Belanger M, Cope ZA, Little GJ, Williams SG, Ash C, Bleckert A, Ragan T, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR,...

Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H

by abbottmj | Dec 7, 2021 | Uncategorized

Kotredes KP, Oblak A, Pandey RS, Lin PB, Garceau D, Williams H, Uyar A, O’Rourke R, O’Rourke S, Ingraham C, Bednarycek D, Belanger M, Cope Z, Foley KE, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Sasner M, Lamb BT, Howell GR.Front...
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The IU/JAX/UCI MODEL-AD Consortium was established with funding from The National Institute on Aging (U54 AG054345-01 and AG054349). Aging studies are also supported by the Nathan Shock Center of Excellence in the Basic Biology of Aging (NIH P30 AG0380770). Contact us: ModelAD@iupui.edu