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Strain Table

Strain Availability Source
Familial AD models   
5XFAD 5XFAD live Bob Vassar
APP/PS1 APP/PS1 live Dave Borchelt
3XTg-AD on B6;129 3XTg-AD on B6;129 live Frank LaFerla
3xTg-AD on 129S4 3xTg-AD on 129S4 cryo MODEL-AD
hTau hTau live Peter Davies
    
    
Late-onset AD-related models   
hAbeta/APOE4 hAbeta/APOE4 Fall 2020 MODEL-AD
hAbeta/APOE3 hAbeta/APOE3 Fall 2020 MODEL-AD
hAbeta/APOE4/Trem2*R47H hAbeta/APOE4/Trem2*R47H live MODEL-AD
    
APOE models   
APOE4/Trem*R47H APOE4/Trem*R47H live MODEL-AD
APOE4 KI APOE4 KI live MODEL-AD
APOE3 KI APOE3 KI live MODEL-AD
APOE2 KI APOE2 KI Fall 2020 MODEL-AD
    
APP models   
hAbeta KI hAbeta KI Fall 2020 MODEL-AD
hAbeta KI hAbeta/APOE4/Trem2*R47H live MODEL-AD
hAbeta-loxP-KI B6J.hAbeta-loxP-KI live MODEL-AD
hAbeta-loxP-KI B6NJ.hAbeta-loxP-KI live MODEL-AD
hAbeta-loxP-KI mixed B6J;B6N.hAbeta-loxP-KI live MODEL-AD
App KO APP KO/APOE4/Trem2*R47H cryo MODEL-AD
    
MAPT (TAU) models   
MAPT(H2)-GR MAPT(H2)-GR Aug-20 Michael Koob
Trem2 models   
Trem2*R47H Trem2*R47H live MODEL-AD
Trem2*Y38C Trem2*Y38C cryo MODEL-AD
Trem2 KO Trem2 KO live MODEL-AD
floxed Trem2 Trem2 flox live MODEL-AD
    
Late-onset AD variants   
Abca7*A1527G Abca7*A1527G/APOE4/Trem2*R47H cryo MODEL-AD
Abca7 KO Abca7 KO/APOE4/Trem2*R47H cryo MODEL-AD
Adamts4 enhancer KO Adamts4 enhancer KO/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Bin1 intron1 SNP/hAbeta/APOE4/Trem2*R47H Bin1 intron 1 SNP/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Ceacam1 KO Ceacam1 KO/APOE4/Trem2*R47H cryo MODEL-AD
Cd2ap promoter SNP Cd2ap promoter SNP/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Clasp2*L163P Clasp2*L163P/APOE4/Trem2*R47H cryo MODEL-AD
hCR1 KI hCR1 cryo MODEL-AD
hCR1 KI hCR1/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Epha1 exon 1 SNP Epha1 exon 1 SNP/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Erc2*N542S Erc2*N542S/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Il1rap exon 2 KO Il1rap exon2 KO/APOE4/Trem2*R47H cryo MODEL-AD
IL1rap exon 3 KO Il2rap exon 3 KO/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Il34*Y213* Il34*Y213*/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Kif21b*T82T Kif21b*T82T/APOE4/Trem2*R47H cryo MODEL-AD
Meox2 KO (HET) Meox2 KO/APOE4/Trem2*R47H 44105 Soriano/MODEL-AD
Mthfr*C677T Mthfr*C677T/APOE4/Trem2*R47H cryo MODEL-AD
Mtmr4*V297G Mtmr4*V297G/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Picalm*H465R Picalm*H465R Fall 2020 MODEL-AD
Pilra*G85R Pilra*G85R/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Plcg2*M28L Plcg2*M28L/APOE4/Trem2*R47H cryo MODEL-AD
Plcg2*P522R Plcg2*P522R/APOE4/Trem2*R47H cryo JAX
Plcg2 KO Plcg2 KO cryo MODEL-AD
Ptk2b intron 5 SNP Ptk2b intron 5 SNP/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Ptprb*D57N Ptprb*D57N/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Scimp upstream SNP Scimp upstream SNP/hAbeta/APOE4/Trem2*R47H Fall 2020 MODEL-AD
Shc2*V433M SNP Shc2*V433M/APOE4/Trem2*R47H cryo MODEL-AD
Slc6a17*P61P SNP Slc6a17*P61P/APOE4/Trem2*R47H cryo MODEL-AD
Snx1*D465N SNP Snx1*A528T/APOE4/Trem2*R47H cryo MODEL-AD
Sorl1*A528T SNP Sorl1*A528T/APOE4/Trem2*R47H cryo MODEL-AD
Sorl1 A528T SNP Sorl1*A528T cryo MODEL-AD