| Common name | Genetic background | Strain Nomenclature | Availability | JAX # | Source |
| Familial AD models | |||||
| 5XFAD | B6J | B6.Cg-Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax | live | 8730 | Bob Vassar |
| APP/PS1 | B6J | B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax | live | 5864 | Dave Borchelt |
| 3XTg-AD | mixed B6; 129 | B6;129-Tg(APPSwe,tauP301L)1Lfa Psen1tm1Mpm/Mmjax | live | 4807 | Frank LaFerla |
| 3xTg-AD | 129 | 129S4.Cg-Tg(APPSwe,tauP301L)1Lfa Psen1tm1Mpm/LfaJ | cryo | 31988 | MODEL-AD |
| hTau | B6J | B6.Cg-Mapttm1(EGFP)KltTg(MAPT)8cPdav/J | live | 5491 | Peter Davies |
| Late-onset AD-related models | |||||
| APOE models | |||||
| APOE4/Trem2*R47H | B6J | B6.Cg-Apoetm1.1(APOE*4)AdiujTrem2em1Adiuj/J | live | 28709 | MODEL-AD |
| APOE4 KI | B6J | B6.Cg-Apoetm1.1(APOE*4)Adiuj/J | live | 27894 | MODEL-AD |
| APOE3 KI | B6J | B6.Cg-Apoeem2(APOE*)Adiuj/J | live | 29018 | MODEL-AD |
| APOE2 KI | B6J | B6.Cg-Apoeem3(APOE*)Adiuj/J | tbd | 29017 | MODEL-AD |
| APP models | |||||
| hAbeta-loxP-KI | mixed B6J; B6N | B6(SJL)-Apptm1.1Aduci/J | live | 30898 | MODEL-AD |
| hAbeta-loxP-KI | B6NJ | B6N(Cg)-Apptm1.1Aduci/J | Jan ’20 | 32013 | MODEL-AD |
| hAbeta KI | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)AdiujAppem#1Adiuj Trem2em1Adiuj/J | live | 30670 | MODEL-AD |
| App KO | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)AdiujAppem2Adiuj Trem2em1Adiuj/J | cryo | 31722 | MODEL-AD |
| Trem2 models | |||||
| Trem2*R47H | B6J | C57BL/6J-Trem2em1Adiuj/J | live | 27918 | MODEL-AD |
| Trem2*Y38C | B6J | C57BL/6J-Trem2em3Adiuj/J | cryo | 29725 | MODEL-AD |
| Trem2 KO | B6J | C57BL/6J-Trem2em2Adiuj/J | live | 27197 | MODEL-AD |
| floxed Trem2 | B6J | B6(C3)-Trem2tm1c(EUCOMM)Wtsi/AdiujJ | live | 29853 | MODEL-AD |
| AD GWAS LOAD variant models | |||||
| Abca7*A1527G SNP | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)AdiujAbca7em#2Adiuj Trem2em1Adiuj/J | live | 30283 | MODEL-AD |
| Abca7 KO | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)AdiujAbca7em#1Adiuj Trem2em1Adiuj/J | live | 30320 | MODEL-AD |
| Ceacam1 KO | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)AdiujCeacam1em#1Adiuj Trem2em1Adiuj/J | live | 30673 | MODEL-AD |
| Clasp2 L163P SNP | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)Adiuj Clasp2em1Adiuj Trem2em1Adiuj/J | cryo | 31944 | MODEL-AD |
| hCR1 KI | B6J | B6(Cg)-Cr2tm1.1(CR2,CR1)How/HowJ | cryo | 27713 | MODEL-AD |
| hCR1 KI | B6J-APOE4/Trem2*R47H | B6.Cg-Cr2tm1(CR2,CR1)How Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J | tbd | 31668 | MODEL-AD |
| Il1rap exon 2 KO | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)AdiujIl1rapem#1Adiuj Trem2em1Adiuj/J | live | 30304 | MODEL-AD |
| Kif21b T82T SNP | B6J-APOE4/Trem2*R47H | B6.Cg-Kif21bem1Adiuj Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J | cryo | 31938 | MODEL-AD |
| Meox2 KO (HET) | B6J-APOE4/Trem2*R47H | B6(Cg)-Apoetm1.1(APOE*4)Adiuj Meox2tm1(cre)Sor Trem2em1Adiuj/J | tbd | 33770 | Soriano/MODEL-AD |
| Mthfr*C677T SNP | B6J-APOE4/Trem2*R47H | B6.Cg-Mthfrem1Adiuj Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J | cryo | 30922 | MODEL-AD |
| Mtmr4*V297G SNP | B6J-APOE4/Trem2*R47H | B6(SJL)-Apoetm1.1(APOE*4)Adiuj Mtmr4em1Adiuj Trem2em1Adiuj/J | tbd | 31950 | MODEL-AD |
| Plcg2*M28L SNP | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)AdiujPlcg2em2Adiuj Trem2em1Adiuj/J | live | 30674 | MODEL-AD |
| Plcg2*P522R | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)AdiujPlcg2em1Msasn Trem2em1Adiuj/J | cryo | 30771 | JAX |
| Plcg2 KO | B6J | B6.Cg-Plcg2em2Adiuj/J | cryo | 29910 | MODEL-AD |
| Shc2*V433M SNP | B6J-APOE4/Trem2*R47H | B6(SJL)-Apoetm1.1(APOE*4)Adiuj Shc2em1Adiuj Trem2em1Adiuj/J | Feb ’20 | 31952 | MODEL-AD |
| Slc6a17*P61P SNP | B6J-APOE4/Trem2*R47H | B6(SJL)-Slc6a17em1Adiuj Apoetm1.1(APOE*4)Adiuj Trem2em1Adiuj/J | tbd | 31948 | MODEL-AD |
| Snx1 D465N SNP | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)Adiuj Snx1em1Adiuj Trem2em1Adiuj/J | cryo | 31942 | MODEL-AD |
| Sorl1 A528T SNP | B6J-APOE4/Trem2*R47H | B6.Cg-Apoetm1.1(APOE*4)Adiuj Sorl1em1Adiuj Trem2em1Adiuj/J | cryo | 31940 | MODEL-AD |