Strain Table

Strain Availability Source
Familial AD models
5XFAD 5XFAD available Bob Vassar
APP/PS1 APP/PS1 available Dave Borchelt
3XTg-AD on B6 3XTg-AD on B6 under dev MODEL-AD
3XTg-AD on B6;129 3XTg-AD on B6;129 available Frank LaFerla
3xTg-AD on 129S4 3xTg-AD on 129S4 available MODEL-AD
hTau hTau available Peter Davies
Late-onset AD-related models
hAbeta/APOE4 hAbeta/APOE4 available MODEL-AD
hAbeta/APOE hAbeta/APOE3 under dev MODEL-AD
hAbeta/APOE4/Trem2*R47H hAbeta/APOE4/Trem2*R47H available MODEL-AD
APOE models
APOE4/Trem*R47H APOE4/Trem*R47H available MODEL-AD
APOE4 KI APOE4 KI available MODEL-AD
APOE3 KI APOE3 KI available MODEL-AD
APOE2 KI APOE2 KI available MODEL-AD
APP models
hAbeta KI hAbeta KI available MODEL-AD
hAbeta KI hAbeta/APOE4/Trem2*R47H available MODEL-AD
hAbeta-loxP-KI B6J.hAbeta-loxP-KI available MODEL-AD
hAbeta-loxP-KI B6NJ.hAbeta-loxP-KI available MODEL-AD
hAbeta-loxP-KI mixed B6J;B6N.hAbeta-loxP-KI available MODEL-AD
App KO

App KO/APOE4/Trem2*R47H available MODEL-AD
MAPT (TAU) models
MAPT(H2)-GR MAPT(H2.1)-GR available Michael Koob
Trem2 models
Trem2*R47H Trem2*R47H available MODEL-AD
Trem2*Y38C Trem2*Y38C available MODEL-AD
Trem2 KO

Trem2 KO available MODEL-AD
floxed Trem2

Trem2 flox available MODEL-AD
Trem2*R47H Trem2*R47H under dev MODEL-AD
Late-onset AD variants
Abca7*A1527G Abca7*A1527G/APOE4/Trem2*R47H available MODEL-AD
Abca7*A1527G Abca7*A1527G/hAbeta/APOE4/Trem2*R47H under dev MODEL-AD
Abca7 KO Abca7 KO/APOE4/Trem2*R47H available MODEL-AD
Abca7*V1613M Abca7*V1613M under dev MODEL-AD
Abi3*S209F Abi3*S209F under dev MODEL-AD
Adamts4 enhancer KO Adamts4 enhancer KO/hAbeta/APOE4/Trem2*R47H available MODEL-AD
Bin1 intron1 SNP Bin1 intron 1 SNP/hAbeta/APOE4/Trem2*R47H available MODEL-AD
Bin1*K358R Bin1*K358R under dev MODEL-AD
Ceacam1 KO Ceacam1 KO/APOE4/Trem2*R47H available MODEL-AD
Cd2ap promoter SNP Cd2ap promoter SNP/hAbeta/APOE4/Trem2*R47H available MODEL-AD
Clasp2*L163P Clasp2*L163P/APOE4/Trem2*R47H available MODEL-AD
CR1-long CR1-long available MODEL-AD
CR1-long CR1-long/APOE4/Trem2*R47H available MODEL-AD
Epha1 exon 1 SNP Epha1 exon 1 SNP/hAbeta/APOE4/Trem2*R47H available MODEL-AD
Erc2*N542S Erc2*N542S/APOE4/Trem2*R47H available MODEL-AD
Il1rap exon 2 KO Il1rap exon 2 KO/APOE4/Trem2*R47H available MODEL-AD
Il1rap exon 3 KO Il1rap exon 3 KO/hAbeta/APOE4/Trem2*R47H under dev MODEL-AD
Il34*Y213* Il34*Y213*/hAbeta/APOE4/Trem2*R47H available MODEL-AD
Kif21b*T82T Kif21b*T82T/APOE4/Trem2*R47H available MODEL-AD
Meox2 KO (HET) Meox2 KO/APOE4/Trem2*R47H available Soriano/MODEL-AD
Mthfr*C677T Mthfr*C677T/APOE4/Trem2*R47H available MODEL-AD
Mthfr*C677T Mthfr*C677T/hAbeta/APOE4/Trem2*R47H under dev MODEL-AD
Mtmr4*V297G Mtmr4*V297G/APOE4/Trem2*R47H available MODEL-AD
Picalm*H465R

Picalm*H465R under dev MODEL-AD
Pilra*G85R Pilra*G85R/hAbeta/APOE4/Trem2*R47H under dev MODEL-AD
Plcg2*M28L Plcg2*M28L/APOE4/Trem2*R47H available MODEL-AD
Plcg2*P522R Plcg2*P522R/APOE4/Trem2*R47H available JAX
Plcg2 KO Plcg2 KO available MODEL-AD
Ptk2b intron 5 SNP Ptk2b intron 5 SNP/hAbeta/APOE4/Trem2*R47H available MODEL-AD
Ptprb*D57N Ptprb*D57N/hAbeta/APOE4/Trem2*R47H available MODEL-AD
Scimp upstream SNP Scimp upstream SNP/hAbeta/APOE4/Trem2*R47H available MODEL-AD
Shc2*V433M Shc2*V433M/APOE4/Trem2*R47H available MODEL-AD
Slc6a17*P61P Slc6a17*P61P/APOE4/Trem2*R47H available MODEL-AD
Snx1*D465N Snx1*D465N/APOE4/Trem2*R47H available MODEL-AD
Sorl1*A528T Sorl1*A528T/APOE4/Trem2*R47H available MODEL-AD
Sorl1 A528T Sorl1*A528T available MODEL-AD
Spi1*rs1377416 Spi1*rs1377416 under dev MODEL-AD