Model organism development and evaluation for late-onset Alzheimer’s disease: MODEL-AD
Adrian L Oblak, Stefania Forner, Paul R Territo, Michael Sasner, Gregory W Carter, Gareth R Howell, Stacey J Sukoff-Rizzo, Benjamin A Logsdon, Lara M Mangravite, Ali Mortazavi, David Baglietto-Vargas, Kim N Green, Grant R MacGregor, Marcelo A Wood, Andrea J...
MODEL-AD Publications June-July 2020
Sukoff Rizzo SJ, Masters A, Onos KD, Quinney S, Sasner M, Oblak A, Lamb BT, Territo PR; MODEL‐AD consortium. Improving preclinical to clinical translation in Alzheimer's disease research. Alzheimers Dement (N Y). 2020 Jun 14;6(1):e12038. doi: 10.1002/trc2.12038....
MODEL-AD Presentations at AAIC 2020
Featured Research Sessions Monday, July 27, 2020: 8:30 AM - 9:30 AM Microbiome in Alzheimer’s Disease: Pathogenesis and Treatment Implications [SFRS1-02 Virtual Room Name: The Hague] Speakers: Dr. Meiyu Geng, Sam Sisodia, Michael Heneka, Bruce...
Transcriptomic stratification of late-onset Alzheimer’s cases reveals novel genetic modifiers of disease pathology
Milind N, Preuss C, Haber A, Ananda G, Mukherjee S, John C, Shapley S, Logsdon BA, Crane PK, Carter GW. PLoS Genet. 2020 Jun 3;16(6):e1008775. doi: 10.1371/journal.pgen.1008775. [Epub ahead of print] PMID: 32492070 [PubMed - as supplied by publisher]...
Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
Pandey RS, Graham L, Uyar A, Preuss C, Howell GR, Carter GW. https://www.ncbi.nlm.nih.gov/pubmed/31878951
Preclinical screening of compounds
The Preclinical Testing Core (PTC) of the MODEL-AD) consortium supports preclinical screening of test compounds nominated by the greater research community. The PTC has established a streamlined preclinical drug testing strategy with go/no-go decision points that...
MODEL-AD Presentations at SfN 2019
Monday, October 21, 2019 Session #354 – 4:15-4:30 PM - McCormick Place: Room S103 Title: Developing mouse models to study late-onset Alzheimer’s Disease D. BAGLIETTO-VARGAS1,2, L. CAI1, M. NGUYEN1, K. HUYNH1, A.C. MARTINI1, L. TRUJILLO-ESTRADA1, C. SOTO3, I....
MODEL-AD Presentations at AAIC 2019
Sunday, July 14, 4:55-5:15 PM, Petree Hall C #F1-07-03 Alzheimer’s Susceptibility Genes Implicate Microglial Activity Julie Williams, PhD1,2; Rebecca Sims, PhD3; Philip Taylor, PhD2; Michael Sasner, PhD4; Harriet M Williams, MPhil4 and Gareth Howell, PhD3,4, (1)UK...