Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study
Oblak AL, Lin PB, Kotredes KP, Pandey RS, Garceau D, Williams HM, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarczyk D, Belanger M, Cope ZA, Little GJ, Williams SG, Ash C, Bleckert A, Ragan T, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW,...
Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H
Kotredes KP, Oblak A, Pandey RS, Lin PB, Garceau D, Williams H, Uyar A, O'Rourke R, O'Rourke S, Ingraham C, Bednarycek D, Belanger M, Cope Z, Foley KE, Logsdon BA, Mangravite LM, Sukoff Rizzo SJ, Territo PR, Carter GW, Sasner M, Lamb BT, Howell GR.Front Aging...
SFN 2021 Posters
MODEL-AD SFN 2021 Posters All times for Neuroscience 2021 are in Central Standard Time. Session Title: Alzheimer's Disease: Genetics, Genomics, and Other Omics Approaches III Virtual Poster Session Time: 11/11/2021 1:30 PM - 2:30 PM Abstract Title: Identification and...
AD/PD 2021 Presentations
Characterization of genetic and environmental influences in a novel mouse model of late-onset AD Adrian L. Oblak Effects of Western Diet in Modeling Late-Onset Alzheimer’s Disease in Laboratory Mice Kevin Kotredes Kotredes P334 ADPD 2021 Diet Determining...
AAIC 2021 Posters
The synergistic role of high-fat diet and genetic predisposition in Alzheimer’s disease. Adrian L. Oblak, Kevin Kotredes, Ravi Pandey, Mike Sasner, Greg Carter, Bruce Lamb and Gareth Howell. Poster #55514, IP-BSP-1 [In-Person Posters] Basic Science & Pathogenesis:...
AD Knowledge Portal Data Release 17.5
The Jax.IU.Pitt_Rat_TgF344-AD Study This is a study of a familial Alzheimer’s disease transgenic rat model expressing human APP with the Swedish mutation (KM670/671NL) and human PSEN1 with the Δ exon 9 mutation. Previously released was beta amyloid and proinflammatory...
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
Christoph Preuss, Ravi Pandey, Erin Piazza, Alexander Fine, Asli Uyar, Thanneer Perumal, Dylan Garceau, Kevin P Kotredes, Harriet Williams, Lara M Mangravite, Bruce T Lamb, Adrian L Oblak, Gareth R Howell, Michael Sasner, Benjamin A Logsdon, MODEL-AD...
Molecular estimation of neurodegeneration pseudotime in older brains
Sumit Mukherjee, Laura Heath, Christoph Preuss, Suman Jayadev, Gwenn A Garden, Anna K Greenwood, Solveig K Sieberts, Philip L De Jager, Nilüfer Ertekin-Taner, Gregory W Carter, Lara M Mangravite, Benjamin A Logsdon. Molecular estimation of neurodegeneration pseudotime...