Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach
Logsdon et al have used data from the AMP-AD consortium to identify consensus gene clusters that are differentially expressed in Alzheimer’s disease. The MODEL-AD consortium has worked with nanoString to develop a transcriptomics panel to assay these modules in mouse...
MODEL-AD Presentations at the 2018 Society for Neuroscience Meeting
Monday, November 5, 1:30pm - 4pm Session 345: Global Efforts to Build More Predictive Animal Models of Neurodegenerative Disease Chair: Bruce T. Lamb, PhD, Indiana University School of Medicine Co-Chair: Rudolph E. Tanzi, PhD, Massachusetts General Hospital, Harvard...
The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
A recent publication from the lab of Christian Haass has shown altered splicing of mouse Trem2 that is dependent upon the presence of the R47H mutation and leads to a cryptic splice site in exon 2 and a deletion of 119 nucleotides. The MODEL-AD project has similar...
New paper on healthspan and lifespan measures in aging mice published
Assessing Healthspan and Lifespan Measures in Aging Mice: Optimization of Testing Protocols, Replicability, and Rater Reliability.
Animal models of AD featured in Nature
The July 25 Nature has an Outlook story featuring the MODEL-AD program: The search for better animal models of Alzheimer's disease.
MODEL-AD presentations at AAIC 2018
Sunday July 22 Poster P1-130 Familial Models_OBLAK_AAIC 2018 -min MODEL-AD: Characterization of Familial AD Models (5xFAD, APP/PS1, hTau, 3xTg-AD) Poster P1-131 MODEL AD overview-min (1) MODEL-AD: Late-Onset Alzheimer’s Disease Models Haβ-KI: A Knock-in Mouse Model...
MODEL-AD presentations at ICMN
Monday June 11 SHORT TALKS I 15:51-16:03 GWAS-based mouse models exhibit distinct transcriptomic signatures of late-onset Alzheimer’s disease Greg Carter (The Jackson Laboratory, USA) Tuesday June 12 SESSION 6: INNATE IMMUNITY AND NEURODEGENERATION 13:10-13:35...
Indiana U. Alzheimer’s symposium
The IU/JAX MODEL-AD Center and the Indiana Alzheimer’s Disease Center hosted a scientific symposium focusing on translational approaches to Alzheimer’s disease featuring speakers from the Stark Neurosciences Institute, The Jackson Lab, Sage Bionetworks and Eli Lilly...