AD Knowledge Portal Data Release 17.5
The Jax.IU.Pitt_Rat_TgF344-AD Study This is a study of a familial Alzheimer’s disease transgenic rat model expressing human APP with the Swedish mutation (KM670/671NL) and human PSEN1 with the Δ exon 9 mutation. Previously released was beta amyloid and proinflammatory...
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
Christoph Preuss, Ravi Pandey, Erin Piazza, Alexander Fine, Asli Uyar, Thanneer Perumal, Dylan Garceau, Kevin P Kotredes, Harriet Williams, Lara M Mangravite, Bruce T Lamb, Adrian L Oblak, Gareth R Howell, Michael Sasner, Benjamin A Logsdon, MODEL-AD...
Molecular estimation of neurodegeneration pseudotime in older brains
Sumit Mukherjee, Laura Heath, Christoph Preuss, Suman Jayadev, Gwenn A Garden, Anna K Greenwood, Solveig K Sieberts, Philip L De Jager, Nilüfer Ertekin-Taner, Gregory W Carter, Lara M Mangravite, Benjamin A Logsdon. Molecular estimation of neurodegeneration pseudotime...
Model organism development and evaluation for late-onset Alzheimer’s disease: MODEL-AD
Adrian L Oblak, Stefania Forner, Paul R Territo, Michael Sasner, Gregory W Carter, Gareth R Howell, Stacey J Sukoff-Rizzo, Benjamin A Logsdon, Lara M Mangravite, Ali Mortazavi, David Baglietto-Vargas, Kim N Green, Grant R MacGregor, Marcelo A Wood, Andrea J...
MODEL-AD Publications June-July 2020
Sukoff Rizzo SJ, Masters A, Onos KD, Quinney S, Sasner M, Oblak A, Lamb BT, Territo PR; MODEL‐AD consortium. Improving preclinical to clinical translation in Alzheimer's disease research. Alzheimers Dement (N Y). 2020 Jun 14;6(1):e12038. doi: 10.1002/trc2.12038....
MODEL-AD Presentations at AAIC 2020
Featured Research Sessions Monday, July 27, 2020: 8:30 AM - 9:30 AM Microbiome in Alzheimer’s Disease: Pathogenesis and Treatment Implications [SFRS1-02 Virtual Room Name: The Hague] Speakers: Dr. Meiyu Geng, Sam Sisodia, Michael Heneka, Bruce...
Transcriptomic stratification of late-onset Alzheimer’s cases reveals novel genetic modifiers of disease pathology
Milind N, Preuss C, Haber A, Ananda G, Mukherjee S, John C, Shapley S, Logsdon BA, Crane PK, Carter GW. PLoS Genet. 2020 Jun 3;16(6):e1008775. doi: 10.1371/journal.pgen.1008775. [Epub ahead of print] PMID: 32492070 [PubMed - as supplied by publisher]...
Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
Pandey RS, Graham L, Uyar A, Preuss C, Howell GR, Carter GW. https://www.ncbi.nlm.nih.gov/pubmed/31878951