nanoString Webinar Thursday, 3/14/19
A gene expression-based screening platform for mouse models of late-onset Alzheimer's disease When: Thursday, March 14, 9:00 a.m. PT Speaker: Greg Carter, PhD, Associate Professor, The Jackson Laboratory Late-onset Alzheimer’s disease (LOAD) is the most common form of...
Identifying and ranking potential driver genes of Alzheimer’s Disease using multi-view evidence aggregation
In Mukherjee et al, we provide a generalizable framework for integration of diverse systems biology outputs to rank and identify new transcriptomic and genetic drivers of Alzheimer's disease. This provides evidence that integration of multiple systems biology...
MODEL-AD Presentations at ADPD Annual Conference March 26-31, 2019, Lisbon, Portugal
Wednesday, March 27th, 08:00-18:00, Exhibition Session Code A7.a DEEP PHENOTYPING OF THE 5XFAD MOUSE MODEL USING THE MODEL-AD PIPELINE ADPD 5xFAD poster AO A. Oblak, H. Williams, G. Carter, S. Sukoff-Rizzo, M. Sasner, P. Territo, G. Howell, B. Lamb. Indiana...
Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach
Logsdon et al have used data from the AMP-AD consortium to identify consensus gene clusters that are differentially expressed in Alzheimer’s disease. The MODEL-AD consortium has worked with nanoString to develop a transcriptomics panel to assay these modules in mouse...
MODEL-AD Presentations at the 2018 Society for Neuroscience Meeting
Monday, November 5, 1:30pm - 4pm Session 345: Global Efforts to Build More Predictive Animal Models of Neurodegenerative Disease Chair: Bruce T. Lamb, PhD, Indiana University School of Medicine Co-Chair: Rudolph E. Tanzi, PhD, Massachusetts General Hospital, Harvard...
The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans.
A recent publication from the lab of Christian Haass has shown altered splicing of mouse Trem2 that is dependent upon the presence of the R47H mutation and leads to a cryptic splice site in exon 2 and a deletion of 119 nucleotides. The MODEL-AD project has similar...
New paper on healthspan and lifespan measures in aging mice published
Assessing Healthspan and Lifespan Measures in Aging Mice: Optimization of Testing Protocols, Replicability, and Rater Reliability.
Animal models of AD featured in Nature
The July 25 Nature has an Outlook story featuring the MODEL-AD program: The search for better animal models of Alzheimer's disease.