Preclinical screening of compounds
The Preclinical Testing Core (PTC) of the MODEL-AD) consortium supports preclinical screening of test compounds nominated by the greater research community. The PTC has established a streamlined preclinical drug testing strategy with go/no-go decision points that...
MODEL-AD Presentations at SfN 2019
Monday, October 21, 2019 Session #354 – 4:15-4:30 PM - McCormick Place: Room S103 Title: Developing mouse models to study late-onset Alzheimer’s Disease D. BAGLIETTO-VARGAS1,2, L. CAI1, M. NGUYEN1, K. HUYNH1, A.C. MARTINI1, L. TRUJILLO-ESTRADA1, C. SOTO3, I....
MODEL-AD Presentations at AAIC 2019
Sunday, July 14, 4:55-5:15 PM, Petree Hall C #F1-07-03 Alzheimer’s Susceptibility Genes Implicate Microglial Activity Julie Williams, PhD1,2; Rebecca Sims, PhD3; Philip Taylor, PhD2; Michael Sasner, PhD4; Harriet M Williams, MPhil4 and Gareth Howell, PhD3,4, (1)UK...
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
Preuss C, Pandey R, Piazza E, Fine A, Uyar A, Perumal T, Garceau D, Kotredes KP, Williams H, Mangravite LM, Lamb BT, Oblak AL, Howell GR, Sasner M, Logsdon BA, Carter GW. A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease....
nanoString Webinar Thursday, 3/14/19
A gene expression-based screening platform for mouse models of late-onset Alzheimer's disease When: Thursday, March 14, 9:00 a.m. PT Speaker: Greg Carter, PhD, Associate Professor, The Jackson Laboratory Late-onset Alzheimer’s disease (LOAD) is the most common form of...
Identifying and ranking potential driver genes of Alzheimer’s Disease using multi-view evidence aggregation
In Mukherjee et al, we provide a generalizable framework for integration of diverse systems biology outputs to rank and identify new transcriptomic and genetic drivers of Alzheimer's disease. This provides evidence that integration of multiple systems biology...
MODEL-AD Presentations at ADPD Annual Conference March 26-31, 2019, Lisbon, Portugal
Wednesday, March 27th, 08:00-18:00, Exhibition Session Code A7.a DEEP PHENOTYPING OF THE 5XFAD MOUSE MODEL USING THE MODEL-AD PIPELINE ADPD 5xFAD poster AO A. Oblak, H. Williams, G. Carter, S. Sukoff-Rizzo, M. Sasner, P. Territo, G. Howell, B. Lamb. Indiana...
Meta-analysis of the human brain transcriptome identifies heterogeneity across human AD coexpression modules robust to sample collection and methodological approach
Logsdon et al have used data from the AMP-AD consortium to identify consensus gene clusters that are differentially expressed in Alzheimer’s disease. The MODEL-AD consortium has worked with nanoString to develop a transcriptomics panel to assay these modules in mouse...