IU/JAX Disease Modeling Project

The Disease Modeling Project aims to create 8 new mouse models relevant to the study of late-onset AD per year.  All of these will be made available for both academic and for-profit use from the Jackson Lab AD Mouse Model Resource.

At least 6 of these new models will be phenotyped annually with a primary screen as shown below.  Those models exhibiting the most clinically relevant AD-like properties will be fully characterized in our deep phenotyping pipeline, with the best models then being passed to the Preclinical Testing Core.

Primary Screen


Deep Phenotyping