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Center Manager position available

The Model Organism Development and Evaluation for Late-onset-Alzheimer’s Disease (MODEL-AD) project seeks a Center Manager for the Jackson Lab site in Bar Harbor, Maine.  MODEL-AD aims to create the next generation of mouse models for AD and develop new therapeutic...

Letters of support for NIA funding proposals

Some of the recent NIA Approved Concepts for funding (see https://www.nia.nih.gov/approved-concepts#collaborative ) encourage the use of mouse models created by the MODEL-AD program.  All of the models generated will be listed on the “Resources” section of...

MODEL-AD Presentations at Neuroscience 2017

MONDAY, NOV. 13, 2017 Session 386 Alzheimer’s Disease: Genetics and Functional Genomic (1:00 – 5:00 PM)   Presentation 386.01 / V26 / 1:00-2:00 Model-ad: Genetic models of late-onset Alzheimer’s disease   Presentation 386.05 / W4 / 1:00-2:00...

MODEL-AD presentations at AAIC

We will be presenting our progress at the Alzheimer’s Association International Conference in London in July. Monday July 17 Genetic Factors of Alzhemer’s Disease: Cross Study Integrative Network Analysis Identification of AD Disease Etiology  P2-101  ...

The Longest Day

The JAX MODEL-AD Center staff and friends participated in the The Longest Day to raise funds and awareness for the care, support and research efforts of the Alzheimer’s Association.  We started the day with sunrise on the top of Cadillac Mountain, then hiked...

APP/PS1 RNAseq data release

RNAseq data from the APP/PS1 model ( B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax ) is now available at the AMP-AD Knowledge Portal. Transcriptomic data has been collected from left hemisphere of both WT and APP/PS1 mouse model. APP/PS1 double transgenic mice...

MODEL-AD Mini-Symposium 5/22/17

The Jackson Laboratory hosted a MODEL-AD Mini-Symposium on Monday, May 22, 2017 from 2:15 to 5:15 p.m in the LCC Auditorium at our Bar Harbor, Maine campus. The symposium included updates from Alzheimer’s Disease experts and was followed by a poster session. For...

New APOE4/Trem2 model

A newly created mouse model of Alzheimer’s disease will be available soon.  This expresses the two strongest genetic risk factors for late-onset AD: the human APOE4 allele and a knock-in of the R47H allele into the mouse Trem2 locus. This has not been fully...