MODEL-AD SFN 2021 Posters
All times for Neuroscience 2021 are in Central Standard Time.
Session Title: Alzheimer’s Disease: Genetics, Genomics, and Other Omics Approaches III
Virtual Poster Session Time: 11/11/2021 1:30 PM – 2:30 PM
Abstract Title: Identification and characterization of UCI MODEL-AD mouse models using single-cell and single-nucleus Split-seq
*H. LIANG, M. GANTUZ, N. REZAIE, G. BALDERRAMA-GUTIERREZ, C. MODEL-AD, A. MORTAZAVI;
Univ. of California, Irvine, Irvine, CA
Session Number: P194.01
Abstract Title: Metabolomics Profiling Reveals Distinct Signatures in the Serum and Brain Metabolites in Mouse Models of Alzheimer’s Disease
*R. PANDEY1, M. ARNOLD2,3, R. KADDURAH-DAOUK4, G. W. CARTER1;
1The Jackson Lab., Bar Harbor, ME; 2Helmholtz Zentrum München, German Res. Ctr. for Envrn. Health, Inst. of Computat. Biology, Neuherberg, Germany; 3Dept. of Psychiatry and Behavioral Sci., Duke University, Durham, NC; 4Psychiatry, Duke Univ. Med. Ctr., Durham, NC
Session Number: P194.02
Abstract Title: Analyzing gene expression during neurodegeneration in a 3xTgAD mouse model at transcriptome level
*N. REZAIE, G. BALDERRAMA-GUTIERREZ, H. LIANG, C. MODEL-AD, A. MORTAZAVI;
Univ. of California, Irvine, Irvine, CA
Session Number: P194.03
Abstract Title: Improved mouse models of the Alzheimer’s disease risk variant Trem2*R47H
*M. SASNER1, G. MACGREGOR2, A. OBLAK3, D. GARCEAU1, K. KOTREDES1, C. PREUSS1, A. UYAR1, R. PANDEY1, P. B.-C. LIN3, A. P.-Y. TSAI3, S. KAWAUCHI2, G. BALDERRAMA-GUTIERREZ2, J. ALCANTARA2, J. NEUMANN2, A. MORTAZAVI2, K. N. GREEN2, G. R. HOWELL1, G. CARTER1, A. J. TENNER2, F. M. LAFERLA2, B. T. LAMB3;
1The Jackson Lab., Bar Harbor, ME; 2Univ. California Irvine, Irvine, CA; 3Stark Neurosciences Res. Inst., Indianapolis, IN
Session Number: P194.04
Abstract Title: Inpp5d regulates the amyloid pathology in alzheimer’s disease
*P. B.-C. LIN1, A. P.-Y. TSAI1, K. NHO2, B. T. LAMB1, A. OBLAK3;
1Stark Neurosciences Res. Inst., Indianapolis, IN; 2Dept. of Radiology & Imaging Sci., Indiana Univ. Sch. of Med., Indianapolis, IN; 3Stark Neurosci. Res. Inst., Indianapolis, IN
Session Number: P194.05
Abstract Title: High Fat Diet Exacerbates the Neuroinflammatory Signature in Mouse Models relevant to Late-Onset Alzheimer’s Disease
*A. L. OBLAK1, K. KOTREDES2, R. PANDEY2, M. SASNER2, S. J. SUKOFF RIZZO3, G. W. CARTER2, B. T. LAMB1, G. R. HOWELL2;
1STARK Neurosci. Res. Inst., Indianapolis, IN; 2The Jackson Lab., Bar Harbor, ME; 3Univ. of Pittsburgh, Pittsburgh, PA
Session Number: P194.07
Session Title: Alzheimer’s Disease: Genetics, Genomics, and Other Omics Approaches VI
Virtual Poster Session Time: 11/9/2021 9:30 AM – 10:30 AM
Abstract Title: Unraveling disease mechanisms in a novel, humanized mouse model of late-onset Alzheimer’s
*K. KOTREDES1, A. OBLAK2, C. PREUSS1, R. PANDEY1, P. R. TERRITO3, S. J. SUKOFF RIZZO4, G. CARTER1, M. SASNER1, G. R. HOWELL5, B. T. LAMB6;
1The Jackson Lab., Bar Harbor, ME; 2STARK Neurosci. Res. Inst., 3Radiology and Imaging Sci., Indiana Univ. Sch. of Med., Indianapolis, IN; 4Dept. of Neurobio. and Dept. of Med. – Aging Inst., Univ. of Pittsburgh Sch. of Med., Pittsburgh, PA; 5Jackson Lab., Bar Harbor, ME; 6Stark Neurosciences Res. Inst., Indianapolis, IN
Session Number: P198.02
Session Title: Effects of Amyloid Beta on Glial Function
Virtual Poster Session Time: 11/10/2021 3:15 PM – 4:15 PM
Abstract Title: TREM2*R47Hem1Aduci; 5xFAD mice display sex-specific differences in plaques and plaque-associated microglia
*K. M. TRAN1,2, S. KAWAUCHI3, S. FORNER1, D. JAVONILLO1, C. DA CUNDA1, J. PHAN1, K. TRAN1, N. REZAIE4, H. LIANG1, A. MORTAZAVI5, A. TENNER1,2,6, F. LAFERLA1,2, G. MACGREGOR3,5, K. GREEN1,2;
1Univ. of California, Irvine, Inst. for Memory Impairments and Neurolog. Disorders, Irvine, CA; 2Univ. of California Irvine, Neurobio. and Behavior, Irvine, CA; 3Univ. of California, Irvine, Transgenic Mouse Facility, Irvine, CA; 4Univ. of California, Irvine, Mathematical, Computat. and Systems Biol., Irvine, CA; 5Univ. of California, Irvine, Dept. of Developmental and Cell Biol., Irvine, CA; 6Univ. of California Irvine, Mol. biology and Biochem., Irvine, CA
Session Number: P201.01
Abstract Title: ABCA7*V1599Mem1Aduci variant in 5xFAD mice mediates differences in amyloid-beta pathology and reactive gliosis
*D. JAVONILLO1, L. A. HOUCHIN1, S. KAWAUCHI2, *J. PHAN3, C. DA CUNHA3, K. TRAN3, G. MILINKEVICIUTE3, A. J. TENNER4, F. M. LAFERLA3, G. R. MACGREGOR4, K. N. GREEN3;
1Univ. of California, Irvine 2Transgenic Mouse Facility, Univ. Lab. Animal Resources, Office of Res., 3Inst. for Memory Impairments and Neurolog. Disorders (UCI MIND), 4Dept. of Developmental and Cell Biol., 1Univ. of California, Irvine, Irvine, CA
Session Number: P201.05
Session Title: Alzheimer’s Disease: Genetics, Genomics, and Other Omics Approaches VII
Virtual Poster Session Time: 11/10/2021 3:30 PM – 4:30 PM
Abstract Title: Connectomic analysis of whole brain network via glucose metabolism in the 5xFAD mouse
*R. M. SILVOLA1, M. VERONESE4, S. PERSOHN2, A. A. BEDWELL2, K. ELDRIDGE2, R. SPEEDY2, P. R. TERRITO3;
1Clin. Pharmacol., 2STARK NEUROSCIENCES, 3NEUROSCIENCE, Indiana Univ. Sch. of Med., Indianapolis, IN; 4King’s Col., London, United Kingdom
Session Number: P197.03
Abstract Title: Plcg2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease
*E. J. MESSENGER1, A. P.-Y. TSAI1, C. DONG1, P. B.-C. LIN4, B. T. CASALI1, M. MOUTINHO4, Y. LIU1, A. OBLAK2, B. T. LAMB4, G. E. LANDRETH3, S. J. BISSEL1, K. NHO1;
2STARK Neurosci. Res. Inst., 3Stark Neurosci. Res. Institute, NB214C, 1Indiana Univ. Sch. of Med., Indianapolis, IN; 4Stark Neurosciences Res. Inst., Indianapolis, IN
Session Number: P197.04
Abstract Title: Impact of PLCG2 Alzheimer’s Disease Risk and Protective Variants on Microglial Biology and Disease Pathogenesis
*A. TSAI1, P. B.-C. LIN1, C. DONG2, M. MOUTINHO1, Y. LIU2, A. OBLAK3, S. J. BISSEL5, K. NHO2, B. T. LAMB1, G. E. LANDRETH4;
1Stark Neurosciences Res. Inst., Indianapolis, IN; 2Indiana university Sch. of Med., Indianapolis, IN; 3STARK Neurosci. Res. Inst., 4Stark Neurosci. Res. Institute, NB214C, Indiana Univ. Sch. of Med., Indianapolis, IN; 5Neuropathology, Univ. Pittsburgh, Pittsburgh, PA
Session Number: P197.05
Abstract Title: Late-onset AD risk mutation PICALMH458R prevents plaque generation in 5xFAD mice
*J. PHAN1, K. M. TRAN1, D. I. JAVONILLO1, C. D. CUNHA1, S. FORNER1, S. KAWAUCHI2, A. J. TENNER1,3,4, F. LAFERLA1,3, G. MACGREGOR2,5, K. GREEN1,3;
1Inst. for Memory Impairments and Neurolog. Disorders, 2Transgenic Mouse Facility, 3Neurobio. and Behavior, 4Mol. biology and Biochem., 5Dept. of Developmental and Cell Biol., Univ. of California, Irvine, Irvine, CA
Session Number: P197.06
Abstract Title: Characterization of functional enhancer variants associated with Alzheimer’s disease
*C. PREUSS1, X. CHEN2, G. CARY1, R. PANDEY1, K. KOTREDES1, D. GARCEAU1, C. THEESFELD2, P. SHANNON3, A. UYAR1, G. R. HOWELL1, M. SASNER1, C. C. FUNK3, O. TROYANSKAYA4, G. CARTER1;
1The Jackson Lab., Bar Harbor, ME; 2Flatiron Institute, Simons Fndn., New York, NY; 3Inst. For Systems Biol., Seattle, WA; 4Lewis-Sigler Inst. for Integrative Genomics, Princeton, NJ
Session Number: P197.07
Abstract Title: Incorporating genetic diversity to improve alignment of mouse models to human Alzheimer’s disease
*K. J. ELK, A. UYAR, D. GARCEAU, D. BEDNARCZYK, R. O’ROURKE, K. KOTREDES, M. SASNER, G. W. CARTER, G. R. HOWELL; The Jackson Lab., Bar Harbor, ME
Session Number: P197.08
Abstract Title: The MODEL-AD Explorer: An open access resource for comparing phenotypic data from mouse models of Alzheimer’s disease
*A. GREENWOOD1, S. GELFAND1, R. PANDEY2, N. REZAIE3, A. L. OBLAK4, S. FORNER3, A. UYAR2, J. MINCER5, M. FAZZA1, M. A. PETERS1, R. YAXLEY1, A. VANDER LINDEN1, J. SCHNEIDER1, A. MORTAZAVI3, L. MANGRAVITE1, F. LA FERLA3, A. TENNER3, B. LAMB4, K. N. GREEN3, G. CARTER2;
1Sage Bionetworks, Seattle, WA; 2The Jackson Lab., Bar Harbor, ME; 3Univ. of California, Irvine, Irvine, CA; 4Indiana Univ., Indianapolis, IN; 5Univ. of Utah, Salt Lake City, UT
Session Number: P197.09
Abstract Title: Phenotypic characterization of UCI MODEL-AD mice using RNA-seq
*M. GANTUZ, H. Y. LIANG, N. REZAIE, G. BALDERRAMA-GUTIERREZ, C. MODEL-AD, A. MORTAZAVI;
Univ. of California, Irvine, Irvine, CA
Session Number: P197.10