The Jax.IU.Pitt_Rat_TgF344-AD Study
This is a study of a familial Alzheimer’s disease transgenic rat model expressing human APP with the Swedish mutation (KM670/671NL) and human PSEN1 with the Δ exon 9 mutation. Previously released was beta amyloid and proinflammatory marker data in 64 male and female rats at 3 and 6 months of age. This release adds: Beta amyloid and proinflammatory marker data for an additional 48 male and female rats at 6, 18 and 24 months of age.
The Jax.IU.Pitt_Levetiracetam-5XFAD Study
This study examines the effects of levetiracetam dosing in 5XFAD mice as part of the MODEL-AD Program. Previously released was autoradiography, positron emission tomography, and pharmacokinetic data. This release adds: Behavioral data including open field, rotarod, spontaneous alternation assessments