Monday, October 21, 2019

Session #354 – 4:15-4:30 PM – McCormick Place: Room S103
Title: Developing mouse models to study late-onset Alzheimer’s Disease
D. BAGLIETTO-VARGAS1,2, L. CAI1, M. NGUYEN1, K. HUYNH1, A.C. MARTINI1, L. TRUJILLO-ESTRADA1, C. SOTO3, I. MORENO-GONZALEZ3, S. VIVEK1,2, F.M. LAFERLA1,2 and MODEL-AD CONSORTIUM
1 Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.; 2 Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA.; 3 The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX 77030, USA.

Tuesday, October 22, 2019

Poster Session #473.01/Poster Board #E20 – 8-9 AM – McCormick Place: Hall A
Title: Lifespan magnetic resonance imaging of novel mouse models of Alzheimer’s disease: Phenotyping and comparisons to healthy aging
A. JULLIENNE1, A. OBENAUS2,4, J. LEE5, E.J. BEHRINGER4, MODEL-AD CONSORTIUM3,6,7,8,9;
1Inst. for Memory Impairments and Neurolog. Disorders (UCI MIND), 2Dept. of Pediatrics, 3Univ. of California, Irvine, Irvine, CA; 4Basic Sci., 5Div. of Physiology, Sch. of Med., Loma Linda Univ., Loma Linda, CA; 6Indiana Univ., Indianapolis, IN; 7Jackson Lab., Bar Harbor, ME; 8Sage Bionetworks, Seattle, WA; 9Univ. of Pittsburg, Pittsburg, PA

Poster Session #473.02/Poster Board #E21 – 9-10 AM – McCormick Place: Hall A
Title: Development and characterization of novel mouse models of late onset Alzheimer’s disease
M. SASNER1, D. GARCEAU1, K. KOTREDES1, A. OBLAK2, C. INGRAHAM2, D. SONI2, H. WILLIAMS1, A. REAGAN1, A. UYAR1, R. PANDEY1, C. PREUSS1, B. LOGSDON4, P.R. TERRITO3, G. CARTER1, B.T. LAMB5, G.R. HOWELL1;
1The Jackson Lab., Bar Harbor, ME; 2STARK Neurosci. Res. Inst.; 3Radiology and Imaging Sci., Indiana Univ. Sch. of Med., Indianapolis, IN; 4Sage Bionetworks, Seattle, WA; 5Stark Neurosciences Res. Inst., Indianapolis, IN

Poster Session #473.03/Poster Board #E22 – 10-11 AM – McCormick Place: Hall A
Title: Characterization and Deep Phenotyping of the 5xfAD Mouse Model by MODEL-AD
S. FORNER for MODEL-AD

Poster Session #473.04/Poster Board #E23 – 11 AM–12 PM – McCormick Place: Hall A
Title: Uncoupling of cerebral blood flow and glucose metabolism in APOE4, TREM2, and APOE4.TREM2 mice
P. B. LIN1, S.A. PERSOHN2, A.A. BEDWELL2, L. JIANG2, K.M. ELDRIDGE2, R. SPEEDY2, K. KOTREDES4, R. PANDEY4, H. WILLIAMS4, A.L. OBLAK3, M. SASNER4, G.R. HOWELL4, G.W. CARTER4, B.T. LAMB1, P. R. TERRITO2
1STARK Neurosciences Res. Inst., Indianapolis, IN; 2Radiology and Imaging Sci., Indiana Univ. Sch. of Med., Indianapolis, IN; 3STARK Neurosci. Res. Inst., Indiana Univ. Sch. Of Med., Indianapolis, IN; 4The Jackson Lab., Bar Harbor, ME

Poster Session #473.05/Poster Board #E24 – 8-9 AM – McCormick Place: Hall A
Title: Multi-Phenotype Comparison of an Apoe4.Trem2*R47H Mouse Model and Human Late-Onset Alzheimer’s Disease
G.W. CARTER,1 R.S. PANDEY,1 K.P. KOTREDES,1 C. PREUSS,1 H. WILLIAMS,1 P. TERRITO,2 A. OBLAK,2 B. LAMB,2 S. RIZZO,1 M. SASNER,1 and G. HOWELL1 of the MODEL-AD CENTER1,2,3
1The Jackson Laboratory, Bar Harbor, Maine, USA 04609; 2Stark Neuroscience Research Institute, Indianapolis, Indiana, USA 46202; 3Sage Bionetworks, Seattle, Washington, USA 98121

Poster Session #473.06/Poster Board #E25 – 9-10 AM – McCormick Place: Hall A
Title: Modeling Trem2 variants in mice
A. L. OBLAK1, H. WILLIAMS3, K. KOTREDES3, M. SASNER3, S. J. SUKOFF RIZZO4, G. CARTER3, G.R. HOWELL3, C. PREUSS3, A. UYAR3, R.S. PANDY3, C. INGRAHAM1, D. SONI1, V. JADHAV1, A.P.-Y. TSAI1, P. R. TERRITO2, B. LOGSDON5, B. T. LAMB1
1Stark Neuroscience Research Institute, Indianapolis, Indiana, USA 46202; 2Radiology and Imaging Sci., Indiana Univ. Sch. of Med., Indianapolis, IN; 3The Jackson Laboratory, Bar Harbor, Maine, USA 04609; 4Univ. of Pittsburg, Pittsburg, PA; 5Sage Bionetworks, Seattle, Washington, USA 98121

Poster Session #473.07/Poster Board #E26 – 10-11 AM – McCormick Place: Hall A
Title: Comparative transcriptome analysis of MODEL-AD mouse models
G. BALDERRAMA-GUTIERREZ and A. MORTAZAVI on behalf of MODEL-AD

Poster Session #473.10/Poster Board #E29 – 10-11 AM – McCormick Place: Hall A
Title: Transcriptomic analysis of chronic levetiracetam treatment in aged 5XFAD mice: Relationship with pharmacokinetics and pharmacodynamics
S.J. SUKOFF RIZZO1, K.D. ONOS2, K. KEEZER3, L. HAYNES3, H. WILLIAMS3, S.K. QUINNEY4, A. MASTERS4, C. BIESDORF DE ALMEIDA4, A. A. BEDWELL4, J.A. MEYER5, C. INGRAHAM6, J. PETERS4, S.A. PERSOHN4, R. SPEEDY4, L. FIGUEIREDO4, K. ELDRIDGE4, M. SASNER3, A. OBLAK6, B.T. LAMB6, G. CARTER3, P.R. TERRITO5
1Univ. of Pittsburgh Sch. of Med., Pittsburgh, PA; 2Res., 3The Jackson Lab., Bar Harbor, ME; 5Radiology and Imaging Sci., 6Stark Neurosci. Res. Inst., 4Indiana Univ. Sch. of Med., Indianapolis, IN

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