Sunday, July 14, 4:55-5:15 PM, Petree Hall C

#F1-07-03
Alzheimer’s Susceptibility Genes Implicate Microglial Activity
Julie Williams, PhD1,2; Rebecca Sims, PhD3; Philip Taylor, PhD2; Michael Sasner, PhD4; Harriet M Williams, MPhil4 and Gareth Howell, PhD3,4, (1)UK Dementia Research Institute, Cardiff University, Cardiff, United Kingdom, (2)UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, United Kingdom, (3)Cardiff University, Cardiff, United Kingdom, (4)The Jackson Laboratory, Bar Harbor, ME, USA

Monday, July 15, 9:30 AM – 4:15 PM, South Hall GH

Poster # P2-131
NOVEL APOE4.TREM2*R47H MOUSE MODEL: Building A Better Tool for Late-Onset Alzheimer’s Disease  2019 AAIC POSTER APOE4Trem2R47H
Kevin P Kotredes, PhD1; Christoph Preuss, PhD1; Ravi S Pandey, PhD2; Harriet M Williams, MPhil1; Paul R Territo, PhD3; Adrian L Oblak, PhD4; Bruce T. Lamb, PhD5; Stacey J Sukoff Rizzo, PhD1; Gregory W Carter, PhD1; Michael Sasner, PhD1; Gareth Howell, PhD1 and MODEL-AD Center, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)The Jackson Laboratory, Farmington, CT, USA, (3)Indiana University School of Medicine, Indianapolis, IN, USA, (4)Stark Neurosciences Research Institute, Indianapolis, IN, USA, (5)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA

Poster #P2-133
Initial Characterization of Novel Mouse Models of Late Onset Alzheimer’s Disease Based on Human Genetic Associations  GWAS models poster 20190709 v2
Michael Sasner, PhD1; Adrian L Oblak, PhD2; Christoph Preuss, PhD1; Dylan Garceau1; Harriett Williams, MS1; Kevin P Kotredes, PhD1; Cynthia Ingraham3; Ravi S Pandey, PhD4; Asli Uyar, PhD1; Disha Soni, MA2; Benjamin A Logsdon, PhD5; Bruce T. Lamb, PhD3; Gregory W Carter, PhD1; Gareth Howell, PhD1 and the MODEL-AD Center, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Stark Neurosciences Research Institute, Indianapolis, IN, USA, (3)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA, (4)The Jackson Laboratory, Farmington, CT, USA, (5)Sage Bionetworks, Seattle, WA, USA

Poster #P2-206
Contribution of Focal Microvascular Disruption to Neuroinflammation and Tau Pathology in a Mouse Model of Impact Concussion and Chronic Traumatic Encephalopathy
Chad A. Tagge, PhD2; Juliet A. Moncaster, PhD1; Amanda Gaudreau-Balderrama, PhD2; Xiao-Lei Zhang, PhD3; Mark W. Wojnarowicz, PhD1; Katharine J. Babcock, MS1; Erich S. Franz, BS2; Sarah E. Chancellor, BS1; John H. Pietro, BS1; Joseph W. O’Brien, MS2; Xiuping Liu1; Noel F. Casey, PhD1; Nicola Lupoli1; Haiyan Lu, MD, PhD4; Olga Kokiko-Cochran, PhD4; Sudad Saman, PhD5; Asami Kondo, PhD6; Xiao Zhou7; Omid Miry3; Linnea R Vose3; Maria Ericsson, BS6; Kristen Onos, PhD8; Ronel Veksler, MD, PhD9; Vlad Senatorov, BS10; Katisha Gopaul3; Chirag Upreti, PhD3; Christopher Nowinski, PhD1; Robert Cantu, MD, PhD1; Victor E. Alvarez, MD11; Ning Hua, PhD1; Yorghos Tripodis, PhD12; Andrew Anderson, PhD13; Gareth Howell, PhD8; Daniela Kaufer, PhD10; Garth F. Hall, PhD5; Kun Ping Lu, MD, PhD14; Richard Ransohoff, MD15; Robin O. Cleveland, PhD16; Neil W Kowall, MD17; Bertrand R. Huber, MD, PhD11; Thor D. Stein, MD, PhD11; Bruce T. Lamb, PhD18; William C. Moss, PhD13; Alon Friedman, MD, PhD9; Patric K. Stanton, PhD3 and Ann C. McKee, MD1, (1)Boston University School of Medicine, Boston, MA, USA, (2)Boston University, Boston, MA, USA, (3)New York Medical College, Valhalla, NY, USA, (4)Cleveland Clinic, Cleveland, OH, USA, (5)University of Massachusetts Lowell, Lowell, MA, USA, (6)Harvard Medical School, Boston, MA, USA, (7)BIDMC, Boston, MA, USA, (8)The Jackson Laboratory, Bar Harbor, ME, USA, (9)Ben-Gurion University, Beersheba, Israel, (10)University of California, Berkeley, Berkeley, CA, USA, (11)VA Boston Healthcare System, Jamaica Plain, MA, USA, (12)Boston University School of Public Health, Boston, MA, USA, (13)Lawrence Livermore National Laboratory, Livermore, CA, USA, (14)BIDMC-Harvard Medical School, Boston, MA, USA, (15)Biogen, Cambridge, MA, USA, (16)University of Oxford, Oxford, United Kingdom, (17)Boston University Alzheimer’s Disease Center, Boston, MA, USA, (18)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA

Poster #P2-105
A Novel Systems Biology Approach to Evaluate Mouse Models of Late Onset Alzheimer’s Disease: Ncounter Mouse AD Panel  AAIC POSTER NANOSTRING_2019_July3rd
Christoph Preuss, PhD1; Ravi S Pandey, PhD2; Alexander Fine, Msc1; Asli Uyar, PhD1; Benjamin A Logsdon, PhD3; Thanneer M Perumal, PhD3; Erin Piazza, PhD4; Elizabeth Rullo, PhD4; Jamie Kuhar, PhD4; Christina Bailey, PhD4; Lara M Mangravite, PhD3; Gareth Howell, PhD1; Michael Sasner, PhD1 and Gregory W Carter, PhD1, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)The Jackson Laboratory, Farmington, CT, USA, (3)Sage Bionetworks, Seattle, WA, USA, (4)NanoString Technologies, Inc., Seattle, WA, USA

Tuesday, July 16, 9:30 AM – 4:15 PM, South Hall GH

Poster #P3-111
Metabolic Assessment of Genetically Distinct Mouse Populations: Strain Matters in Mouse Models of Alzheimer’s Disease
Kristen Onos, PhD1; Kelly J. Keezer1; Jubilee Ajiboye1; Caroline Wise, MS1; Michael Sasner, PhD1; Gareth Howell, PhD1,2,3 and Heidi Kocalis, PhD1, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Cardiff University, Cardiff, United Kingdom, (3)Tufts University, Boston, MA, USA

Poster #P3-142
Stratification of Alzheimers Patients Using Postmortem Brain Co-Expression Data Reveals Novel Genetic Modifiers Mediating Inflammatory Aging  AAIC POSTER AMPAD_MODULE_MAPPING_2019_July3rd
Christoph Preuss, PhD1; Benjamin A Logsdon, PhD2; Nikhil Milind, Bsc1; Annat Harber, PhD1; Asli Uyar, PhD1; Ravi S Pandey, PhD3; Thanneer M Perumal, PhD2; Lara M Mangravite, PhD2; Gareth Howell, PhD1; Michael Sasner, PhD1; Shubhabrata Mukherjee, PhD4; Paul K Crane, MD, MPH4; Gregory W Carter, PhD1 and MODEL-AD consortium, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Sage Bionetworks, Seattle, WA, USA, (3)The Jackson Laboratory, Farmington, CT, USA, (4)University of Washington, Seattle, WA, USA

Poster #P3-069
Human Wild Type Aβ Knock-in Mice As a Basis to Study Sporadic Alzheimer’s Disease
David Baglietto-Vargas, Ph.D1; Stefania Forner, Ph.D1; Lena Cai, BS2; Alessandra Cadete Martini, Ph.D1; Laura Trujillo-Estrada, Ph.D1; Shan Jiang, PhD3; Enikö Kramár, PhD4; Cristina Nuñez-Diaz5; Mohammad Shahnawaz6; Dina P Matheos, PhD7; Xinyi Ma, PhD8; Celia Da Cunha1; Claudio Soto, PhD9; Antonia Gutierrez, PhD10; Ines Moreno-Gonzalez, PhD9; Grant R MacGregor, Ph.D2; Kim N Green, PhD2; Marcelo A Wood, Ph.D2; Ali Mortazavi, Ph.D2; Andrea Tenner, Ph.D.2 and Frank LaFerla, Ph.D1, (1)University of California – Irvine, Irvine, CA, USA, (2)University of California, Irvine, Irvine, CA, USA, (3)Department of Developmental and Cell Biology, University of California., Irvine, CA, USA, (4)Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA, (5)Department of Cell Biology, Genetic and Physiology, Faculty of Sciences, Biomedical Research Institute of Malaga (IBIMA), Networking Research Center on Neurodegenerative Diseases (CIBERNED), University of Malaga, Malaga, Spain, (6)The Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin Street,, Houston, TX, USA, (7)Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA, (8)Department of Developmental and Cell Biology, University of California, Irvine, CA, USA, (9)The University of Texas Health Science Center at Houston, Houston, TX, USA, (10)Dept. Cell Biology, Faculty of Sciences, University of Malaga. CIBERNED. IBIMA., MALAGA, Spain

Wednesday, July 17, 9:30 AM – 4:15 PM, South Hall GH

Poster #P4-079
Critical Evaluation of the Pharmacokinetics of Verubecestat in Aged 5XFAD Mice  PTC AAIC POSTER 2019 – FINAL
Paul R Territo, PhD1; Sara K Quinney, PhD1; Carla Biesdorf, PhD2; Kristen Onos, PhD3; Leslie Haynes3; Kelly J. Keezer3; Jill A Meyer1; Jonathan Peters1; Scott C Persohn1; Amanda Bedwell2; Kierra Eldridge2; Rachael Speedy2; Michael Sasner, PhD3; Gareth Howell, PhD3; Harriet M Williams, MPhil3; Adrian L Oblak, PhD1; Bruce T. Lamb, PhD4 and Stacey J Sukoff Rizzo, PhD3, (1)Indiana University School of Medicine, Indianapolis, IN, USA, (2)Indiana University School of Medicine, INDIANAPOLIS, IN, USA, (3)The Jackson Laboratory, Bar Harbor, ME, USA, (4)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA

Poster #P4-098
Transcriptomic Alterations Driven By the Trem2*R47H Allele Vary across Different Transgenic Mouse Models
Asli Uyar, PhD1; Adrian L Oblak, PhD2; Harriet M Williams, MPhil1; Ravi S Pandey, PhD3; Kevin P Kotredes, PhD1; Christoph Preuss, PhD1; Benjamin A Logsdon, PhD4; Stacey J Sukoff Rizzo, PhD1; Gareth Howell, PhD1; Bruce T. Lamb, PhD5; Michael Sasner, PhD1 and Gregory W Carter, PhD1, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Indiana University School of Medicine, Indianapolis, IN, USA, (3)The Jackson Laboratory, Farmington, CT, USA, (4)Sage Bionetworks, Seattle, WA, USA, (5)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA

Poster #P4-091
The Trem2*R47H Variant Alters Expression and Function in Mouse Models of Alzheimer’s Disease  Trem2R47HFINAL
Adrian L Oblak, PhD1,2; Harriet M Williams, MPhil3; Vaishnavi Jadhav1,2; Andy Tsai1,2; Disha Soni, MA1,2; Cynthia Ingraham4; Kevin P Kotredes, PhD3; Asli Uyar, PhD3; Ravi S Pandey, PhD5; Christoph Preuss, PhD3; Ben Logsdon, PhD6; Paul R Territo, PhD2; Stacey J Sukoff Rizzo, PhD3; Michael Sasner, PhD3; Gregory W Carter, PhD3; Gareth Howell, PhD3; Bruce T. Lamb, PhD4 and MODEL-AD Consortium, (1)Stark Neurosciences Research Institute, Indianapolis, IN, USA, (2)Indiana University School of Medicine, Indianapolis, IN, USA, (3)The Jackson Laboratory, Bar Harbor, ME, USA, (4)Indiana University, Stark Neurosciences Research Institute, Indianapolis, IN, USA, (5)The Jackson Laboratory, Farmington, CT, USA, (6)Sage Bionetworks, Seattle, WA, USA

Poster #P4-119
Molecular Estimation of Alzheimer’s Disease Progression
Sumit Mukherjee, PhD1; Christoph Preuss, PhD2; Anna K Greenwood, PhD1; Suman Jayadev, MD3; Gwenn A Garden, MD, PhD3; Gregory W Carter, PhD2; Lara M Mangravite, PhD1 and Benjamin A Logsdon, PhD1, (1)Sage Bionetworks, Seattle, WA, USA, (2)The Jackson Laboratory, Bar Harbor, ME, USA, (3)University of Washington, Seattle, WA, USA

Poster #P4-087
A Common Risk Variant in the MTHFR Gene Contributes to Cerebrovascular Dysfunction in Mixed Dementia
Alaina M Reagan, PhD1; Kevin P Kotredes, PhD1; Harriet M Williams, MPhil1; Rita O’Rourke1; Sarah O’Rourke1; Gregory W Carter, PhD1,2; Michael Sasner, PhD1; Gareth Howell, PhD1,2 and MODEL-AD Center, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Tufts University, Boston, MA, USA

Wednesday, July 17, 4:15-4:30 PM, 502 AB

#04-09-01
Leveraging Mouse Genetic Diversity to Investigate the Role of Brain Myeloid Cells in Alzheimer’s Disease
Hongtian Yang, PhD1; Kristen Onos, PhD1; Asli Uyar, PhD1; Kwangbom Choi, PhD1; Kelly J. Keezer1; Rita O’Rourke1; Sarah O’Rourke1; Michael Sasner, PhD1; Gregory W Carter, PhD1,2 and Gareth Howell, PhD1,2, (1)The Jackson Laboratory, Bar Harbor, ME, USA, (2)Tufts University, Boston, MA, USA

Thursday, July 18, 11:45 AM – 12:00 PM, 403 AB

#05-10-01
Enhanced Function of PLCg2 Variant P522R in Macrophages and Microglia Is Associated with Protection from Alzheimer’s Disease
Emily Maguire, PhD1; Georgina E Menzies, PhD1; Thomas Ernest James Philips, PhD1; Emma L Cope, PhD2; Magdalena Czubala, PhD3; Neil Evans1; Gareth Howell, PhD4,5; Harriet M Williams, MPhil4,5; Michael Sasner, PhD5; Emyr Lloyd-Evans, PhD2; Rebecca Sims, PhD6; Julie Williams, PhD1; Nicholas D Allen, PhD1,2 and Philip Taylor, PhD1,3, (1)UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, United Kingdom, (2)School of Biosciences, Cardiff University, Cardiff, United Kingdom, (3)Systems Immunity Research Institute, Cardiff University, Cardiff, United Kingdom, (4)Cardiff University, Cardiff, United Kingdom, (5)The Jackson Laboratory, Bar Harbor, ME, USA, (6)Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, United Kingdom

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