A gene expression-based screening platform for mouse models of late-onset Alzheimer’s disease
When: Thursday, March 14, 9:00 a.m. PT
Speaker: Greg Carter, PhD, Associate Professor, The Jackson Laboratory
Late-onset Alzheimer’s disease (LOAD) is the most common form of dementia worldwide, but to-date animal models of Alzheimer’s have focused on rare familial mutations. This is due to a lack of frank neuropathology from models based on common disease genes. Recent multi-cohort studies of postmortem human brain transcriptomes have identified a set of 30 gene co-expression modules associated with LOAD, providing a molecular catalog of relevant endophenotypes. Join this webinar to learn how to rapidly and reproducibly assess disease relevance of potential LOAD mouse models using gene expression analysis.
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